Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Aif1tm1(icre)Mabe
Name:	allograft inflammatory factor 1; targeted mutation 1, Manabu Abe
MGI ID:	MGI:6193625
Synonyms:	Iba1-iCre
Gene:	Aif1  Location: Chr17:35389967-35394977 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Aif1tm1(icre)Mabe page

Germline Transmission:	Earliest citation of germline transmission: J:263738
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Aif1tm1(icre)Mabe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aif1 (MGI:1343098)   Mutation details: A vector was constructed to insert an improved cre recombinase, IRES, EGFP and an Frt-flanked neomycin cassette into the translation initiation site (in-frame) of the Aif1 gene by homologous recombination in RENKA ES cells. (J:263738)

Activity:	Tissue activity of this recombinase allele
Driver:	Aif1 (mouse) Summary of all recombinase alleles driven by Aif1. Comparative matrix view of recombinase activities Alliance mouse Aif1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aif1 Mutation:	35 strains or lines available

Original:	J:263738 Nakayama H, et al., Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nat Commun. 2018 Jul 19;9(1):2830
All:	1 reference(s)