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Tg(HLA-DRA*0101,HLA-DRB1*1501)24Dma
Transgene Detail
Summary
Symbol: Tg(HLA-DRA*0101,HLA-DRB1*1501)24Dma
Name: transgene insertion 24, Daniel M Altmann
MGI ID: MGI:6189221
Synonyms: HLA-DR1501
Transgene: Tg(HLA-DRA*0101,HLA-DRB1*1501)24Dma  Location: unknown  
Alliance: Tg(HLA-DRA*0101,HLA-DRB1*1501)24Dma page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details: A 24 kb BamHI fragment of cosmid Mann 4.2, containing allele HLA-DRA1*0101 and 5' and 3' flanking sequence, and clone 11, a full-length DRB1*1501 allele cosmid encompassing extensive flanking 5' and 3' regulatory sequence, were microinjected into oocytes. Mice with this transgene express the human HLA-DR15 serotype. (J:96561)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:96561 Ellmerich S, et al., High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol. 2005 Feb 15;174(4):1938-46
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory