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Gene Expression Data
Assay Details
Assay
Reference: J:124126 Hunter MP, et al., The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol. 2007 Aug 15;308(2):355-67
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6162546
Gene symbol: Hnf4a
Gene name: hepatic nuclear factor 4, alpha
Antibody: Anti-HNF-4 alpha (C-19, sc-6556)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Assay notes: Authors state that both Hhex+/- and Hhexflox/- littermates were used as controls in comparison to Hhex conditional null mutants.
Results
Specimen 3E: embryonic day 16.5; Hhextm1Cwb/Hhex+ (more )
Structure Level Pattern Image Note
TS24: duodenum epithelium Strong 3E
TS24: extrahepatic bile duct epithelium Ambiguous 3E Authors state expression was essentially absent in extrahepatic bile duct.
Specimen 3G: embryonic day 16.5; Hhextm1Cwb/Hhex+ (more )
Structure Level Pattern Image Note
TS24: duodenum epithelium Strong Regionally restricted 3G Strong nuclear expression in duodenal epithelium.
TS24: extrahepatic bile duct epithelium Trace 3G Authors report very weak expression in extrahepatic bile duct.
Specimen 4A: embryonic day 13.5; Hhextm1Cwb/Hhex+ (more )
Structure Level Pattern Image Note
TS21: liver parenchyma Present Regionally restricted 4A Expression in hepatoblasts in the liver.
Specimen 4C: embryonic day 13.5; Hhextm1Cwb/Hhex+ (more )
Structure Level Pattern Image Note
TS21: liver parenchyma Present Regionally restricted 4C Expression in hepatoblasts in the liver.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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