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Gene Expression Data
Assay Details
Assay
Reference: J:124120 Rebustini IT, et al., Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev Biol. 2007 Aug 1;308(1):15-29
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6162499
Gene symbol: Lama5
Gene name: laminin, alpha 5
Reporter: lacZ
Direct Detection
Results
Specimen 1A Lama5+/-: embryonic day 13.0; Lama5Gt1Jhm/Lama5+ (more )
Structure Level Pattern Image Note
TS21: sublingual gland primordium epithelium Present Widespread 1A Lama5+/- Expression throughout submandibular and sublingual epithelium.
TS21: submandibular gland primordium epithelium Present Widespread 1A Lama5+/- Expression throughout submandibular and sublingual epithelium.
Specimen 1A Lama+-/-: embryonic day 13.0; Lama5Gt1Jhm/Lama5Gt1Jhm (more )
Structure Level Pattern Image Note
TS21: submandibular gland primordium Present Regionally restricted 1A Lama5-/- Authors report the homozygous mutant sbmandibular gland was developmentally delayed by ~1 day; the first round of cleft formation had not occurred although the end bud was enlarged.
TS21: sublingual gland primordium Ambiguous 1A Lama5-/- The sublingual gland had not formed.
Specimen 1B: embryonic day 13.0; Lama5Gt1Jhm/Lama5Gt1Jhm (more )
Structure Level Pattern Image Note
TS21: submandibular gland primordium Present 1B
TS21: sublingual gland primordium Ambiguous 1B Authors report a slight thickening of the oral epithelium was observed in place of the sublingual gland.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory