Gene Expression Data
Assay Details
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Assay
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Reference:
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J:121343
Lahteenmaki M, et al., Increased apoptosis of parasympathetic but not enteric neurons in mice lacking GFRalpha2. Dev Biol. 2007 May 1;305(1):325-32
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:6161699
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Gene symbol:
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Casp3
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Gene name:
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caspase 3
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Results
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Specimen
E15 WT Sympathetic:
embryonic day 15.5
(more  )
Specimen
E15 WT Sympathetic:
(close  )
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Genetic Background:
|
involves: C57BL/6JOlaHsd
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Age:
|
embryonic day 15.5
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Sex:
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Not Specified
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|
Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: paravertebral ganglion |
Present |
|
|
Authors state that the period of progammed cell death in sympathetic ganglia starts around E15.
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Specimen
E15 KO Sympathetic:
(close )
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Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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Mutant Allele(s):
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Gfra2tm1Msa/Gfra2tm1Msa
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Age:
|
embryonic day 15.5
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Sex:
|
Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Specimen
E16 WT Sympathetic:
embryonic day 16.5
(more )
Specimen
E16 WT Sympathetic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
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|
Age:
|
embryonic day 16.5
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|
Sex:
|
Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
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Specimen
E16 KO Sympathetic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
E17 WT Sympathetic:
embryonic day 17.5
(more )
Specimen
E17 WT Sympathetic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
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|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: paravertebral ganglion |
Strong |
|
|
Authors state programmed cell death increase towards birth and continues postnally.
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Specimen
E17 KO Sympathetic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
|
Specimen
P0 WT Sympathetic:
postnatal day 0.5
(more )
Specimen
P0 WT Sympathetic:
(close )
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Genetic Background:
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involves: C57BL/6JOlaHsd
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Age:
|
postnatal day 0.5
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Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: paravertebral ganglion |
Strong |
|
|
Authors state programmed cell death increase towards birth and continues postnally.
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Specimen
P0 KO Sympathetic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
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|
Age:
|
postnatal day 0.5
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Sex:
|
Not Specified
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Type:
|
section
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Fixation:
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4% Paraformaldehyde
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Specimen
E15 WT Sensory (DRG):
embryonic day 15.5
(more )
Specimen
E15 WT Sensory (DRG):
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
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|
Age:
|
embryonic day 15.5
|
|
Sex:
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Not Specified
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Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: dorsal root ganglion |
Strong |
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Authors state the percentage of expressing neurons was high at E15.5.
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Specimen
E15 KO Sensory (DRG):
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 15.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
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Fixation:
|
4% Paraformaldehyde
|
Specimen
E16 WT Sensory (DRG):
embryonic day 16.5
(more )
Specimen
E16 WT Sensory (DRG):
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
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|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
E16 KO Sensory (DRG):
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
E17 WT Sensory (DRG):
embryonic day 17.5
(more )
Specimen
E17 WT Sensory (DRG):
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
E17 KO Sensory (DRG):
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
P0 WT Sensory (DRG):
postnatal day 0
(more )
Specimen
P0 WT Sensory (DRG):
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
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Age:
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postnatal day 0
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Sex:
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Not Specified
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Type:
|
section
|
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Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: dorsal root ganglion |
Ambiguous |
|
|
Authors state that programmed cell death is over by birth.
|
Specimen
P0 KO Sensory (DRG):
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
postnatal day 0
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Specimen
E15 WT Enteric:
embryonic day 15.5
(more )
Specimen
E15 WT Enteric:
(close )
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Genetic Background:
|
involves: C57BL/6JOlaHsd
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|
Age:
|
embryonic day 15.5
|
|
Sex:
|
Not Specified
|
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Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: enteric nervous system |
Ambiguous |
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|
Authors report expression is virtually lacking in the developine enteric nervous system.
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Specimen
E15 KO Enteric:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 15.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: enteric nervous system |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
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Specimen
E16 WT Enteric:
embryonic day 16.5
(more )
Specimen
E16 WT Enteric:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: enteric nervous system |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
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Specimen
E16 KO Enteric:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: enteric nervous system |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
|
Specimen
E17 WT Enteric:
embryonic day 17.5
(more )
Specimen
E17 WT Enteric:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: enteric nervous system |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
|
Specimen
E17 KO Enteric:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: enteric nervous system |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
|
Specimen
P0 WT Enteric:
postnatal day 0
(more )
Specimen
P0 WT Enteric:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: enteric ganglion |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
|
Specimen
P0 KO Enteric:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: enteric ganglion |
Ambiguous |
|
|
Authors report expression is virtually lacking in the developine enteric nervous system.
|
Specimen
E15 WT intrapancreatic:
embryonic day 15.5
(more )
Specimen
E15 WT intrapancreatic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 15.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: pancreas |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
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| TS23: parasympathetic ganglion |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
|
Specimen
E15 KO intrapancreatic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 15.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS23: pancreas |
Present |
Regionally restricted |
|
No significant different in percentage of expressing cells between wild type and mutant embryos.
|
| TS23: parasympathetic ganglion |
Present |
Regionally restricted |
|
No significant different in percentage of expressing cells between wild type and mutant embryos.
|
Specimen
E16 WT intrapancreatic:
embryonic day 16.5
(more )
Specimen
E16 WT intrapancreatic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: pancreas |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
|
| TS24: parasympathetic ganglion |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
|
Specimen
E16 KO intrapancreatic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 16.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS24: pancreas |
Strong |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
| TS24: parasympathetic ganglion |
Strong |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
Specimen
E17 WT intrapancreatic:
embryonic day 17.5
(more )
Specimen
E17 WT intrapancreatic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: pancreas |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
|
| TS25: parasympathetic ganglion |
Present |
Regionally restricted |
|
Authors state expressing-cells were relatively numerous in intrapancreatic ganglia between E15 and P0.
|
Specimen
E17 KO intrapancreatic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: pancreas |
Very strong |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
| TS25: parasympathetic ganglion |
Very strong |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
Specimen
P0 WT intrapancreatic:
postnatal day 0
(more )
Specimen
P0 WT intrapancreatic:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: pancreas |
Weak |
Regionally restricted |
|
Authors state that intrapancreatic neurons undergo programmed cell death during normal development.
|
| TS27: parasympathetic ganglion |
Weak |
Regionally restricted |
|
Authors state that intrapancreatic neurons undergo programmed cell death during normal development.
|
Specimen
P0 KO intrapancreatic:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: pancreas |
Present |
Regionally restricted |
|
Authors report the percentage of expressing neurons was no longer clearly elevated.
|
| TS27: parasympathetic ganglion |
Present |
Regionally restricted |
|
Authors report the percentage of expressing neurons was no longer clearly elevated.
|
Specimen
E17 WT SMG:
embryonic day 17.5
(more )
Specimen
E17 WT SMG:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
E17 KO SMG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
embryonic day 17.5
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS25: submandibular ganglion |
Present |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
Specimen
P0 WT SMG:
postnatal day 0
(more )
Specimen
P0 WT SMG:
(close )
|
Genetic Background:
|
involves: C57BL/6JOlaHsd
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
Specimen
P0 KO SMG:
(close )
|
Genetic Background:
|
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
|
Mutant Allele(s):
|
Gfra2tm1Msa/Gfra2tm1Msa
|
|
Age:
|
postnatal day 0
|
|
Sex:
|
Not Specified
|
|
Type:
|
section
|
|
Fixation:
|
4% Paraformaldehyde
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS27: submandibular ganglion |
Strong |
|
|
Percentage of expressing neurons significantly increased in mutant compared with wildtype mice.
|
|
Analysis Tools