Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(hs643-cre/ERT2,-GFP)838Jlr
Name:	transgene insertion 838, John Rubenstein
MGI ID:	MGI:6160935
Synonyms:	643-CreER-IRES-GFP, Tg(ELAVL2-cre/ERT2, GFP)838Jlr
Transgene:	Tg(hs643-cre/ERT2,-GFP)838Jlr  Location: unknown
Alliance:	Tg(hs643-cre/ERT2,-GFP)838Jlr page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Tg(hs643-cre/ERT2,-GFP)838Jlr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note human hs643   Mutation details: This transgene contains the human enhancer element hs643 -- which is flanked on human Chr 9 by the long intergenic non-protein coding RNA 1239 (LINC01239) and ELAV like RNA binding protein 2 (ELAVL2) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus. (J:214335)

Activity:	Tissue activity of this recombinase allele
Driver:	hs643 (human) Summary of all recombinase alleles driven by hs643.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:214335 Pattabiraman K, et al., Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 4;82(5):989-1003
All:	1 reference(s)