Kdr Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:256995 Yu B, et al., CCDC134 serves a crucial role in embryonic development. Int J Mol Med. 2018 Jan;41(1):381-390
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:6160743
Gene symbol:	Kdr
Gene name:	kinase insert domain protein receptor

Antibody:	anti-Vegfr-2 (ab2349)
Detection system:	horseradish peroxidase

Results

Specimen 6A Vegfr-2 +/+: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: liver vasculature	Present	Regionally restricted	6A Vegfr-2 +/+	Expression in vascular endothelial cells.

Specimen 6A Vegfr-2 +/-: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: liver vasculature	Present	Regionally restricted	6A Vegfr-2 +/-	Expression in vascular endothelial cells.

Specimen 6A Vegfr-2 -/-: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134^tm1.2Jhua (more

)

Structure	Level	Pattern	Image	Note
TS21: liver vasculature	Present	Regionally restricted	6A Vegfr-2 -/-	Discontinuous endothelial cell barrier in livers of -/- compared to +/+ and +/- embryos.

6B +/+ upper ©

Specimen 6B +/+ upper: embryonic day 13.5 (more

)

Structure	Level	Image	Note
TS21: forebrain	Present	6B +/+ upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.
TS21: hindbrain	Present	6B +/+ upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.
TS21: midbrain	Present	6B +/+ upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.

6B +/+ lower ©

Specimen 6B +/+ lower: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: brain vascular element	Present		6B +/+ lower	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.

6B +/- upper ©

Specimen 6B +/- upper: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134⁺ (more

)

Structure	Level	Image	Note
TS21: forebrain	Present	6B +/- upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.
TS21: hindbrain	Present	6B +/- upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.
TS21: midbrain	Present	6B +/- upper	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.

6B +/- lower ©

Specimen 6B +/- lower: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134⁺ (more

)

Structure	Level	Pattern	Image	Note
TS21: brain vascular element	Present		6B +/- lower	Expression in both cerebral tissue and blood vessels in forebrain, midbrain and hindbrain.

6B -/- upper ©

Specimen 6B -/- upper: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134^tm1.2Jhua (more

)

Structure	Level	Image	Note
TS21: forebrain	Present	6B -/- upper	Authors report overall brain disorganization in -/- mutants compared with littermates.
TS21: hindbrain	Present	6B -/- upper	Authors report overall brain disorganization in -/- mutants compared with littermates.
TS21: midbrain	Present	6B -/- upper	Authors report overall brain disorganization in -/- mutants compared with littermates.

6B -/- lower ©

Specimen 6B -/- lower: embryonic day 13.5; Ccdc134^tm1.2Jhua/Ccdc134^tm1.2Jhua (more

)

Structure	Level	Pattern	Image	Note
TS21: brain vascular element	Present		6B -/- lower	Authors report significant reduction of vascular density in -/- mutants compared with littermates.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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