Nphp3tm1.1Nakaj
Targeted Allele Detail
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| Symbol: |
Nphp3tm1.1Nakaj |
| Name: |
nephronophthisis 3 (adolescent); targeted mutation 1.1, Yoshiro Nakajima |
| MGI ID: |
MGI:6159873 |
| Synonyms: |
Nphp3G2A |
| Gene: |
Nphp3 Location: Chr9:103879743-103921010 bp, + strand Genetic Position: Chr9, 56.11 cM
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| Alliance: |
Nphp3tm1.1Nakaj page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:261989
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| Parent Cell Line: |
B6-3i/HK3i (ES Cell)
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| Strain of Origin: |
C57BL/6NJcl
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| Allele Type: |
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Targeted (Altered localization) |
| Mutation: |
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Single point mutation
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Mutation details: A GGC -> GCC (G2A) mutation was inserted in exon 1 and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation disrupts targeting of the protein to the cilia.
(J:261989)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nphp3 Mutation: |
77 strains or lines available
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| Original: |
J:261989 Nakajima Y, et al., The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. Kidney Int. 2018 May;93(5):1108-1117 |
| All: |
1 reference(s) |
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Analysis Tools
