Tg(Pbsn-PKN1*)#Bmp
Transgene Detail
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| Symbol: |
Tg(Pbsn-PKN1*)#Bmp |
| Name: |
transgene insertion, Bryce M Paschal |
| MGI ID: |
MGI:6159652 |
| Synonyms: |
PbPKN1deltaN |
| Transgene: |
Tg(Pbsn-PKN1*)#Bmp Location: unknown
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| Alliance: |
Tg(Pbsn-PKN1*)#Bmp page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Pbsn-PKN1*)#Bmp expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PKN1 (5585) |
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expresses a constitutively active mutant form of transcript variant 2 |
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Mutation details: The -244 to -96 region of Pbsn promoter linked to androgen receptor binding sites 1 and 2 drives expression of a human PKN1 cDNA transcript variant 2 (NM_002741) with mutations of K644E, T774E, S916A, and N-terminal deletion of 1-568 amino acids. The protein expressed by this transgene is constitutively active.
(J:256597)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:256597 Yang CS, et al., The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Prostate. 2017 Nov;77(15):1452-1467 |
| All: |
1 reference(s) |
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Analysis Tools
