Scarb1tm1.1Okoch
Targeted Allele Detail
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Symbol: |
Scarb1tm1.1Okoch |
Name: |
scavenger receptor class B, member 1; targeted mutation 1.1, Olivier Kocher |
MGI ID: |
MGI:6158932 |
Synonyms: |
Srb1deltaCT, SR-BIdeltaCT |
Gene: |
Scarb1 Location: Chr5:125354151-125418158 bp, - strand Genetic Position: Chr5, 64.11 cM
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Alliance: |
Scarb1tm1.1Okoch page
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Germline Transmission: |
Earliest citation of germline transmission:
J:237430
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Parent Cell Line: |
iTL BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The targeting construct is designed to insert a point mutation in exon 12, and an FRT-flanked neomycin resistance (neo) cassette downstream of exon 12. The point mutation at amino acid 507 results in an alanine change to a stop codon. Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:237430)
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Original: |
J:237430 Pal R, et al., Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Am J Physiol Heart Circ Physiol. 2016 Dec 01;311(6):H1392-H1408 |
All: |
1 reference(s) |
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