Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tlr4tm1.1Gbrt
Name:	toll-like receptor 4; targeted mutation 1.1, Gregory M Barton
MGI ID:	MGI:6156379
Synonyms:	TLR4YFP
Gene:	Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4tm1.1Gbrt page

Germline Transmission:	Earliest citation of germline transmission: J:305328
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Epitope tag, Reporter) Mutation:    Insertion   Mutation details: The targeting vector was designed to insert a hemagglutinin (HA) tag, followed by an internal ribosome entry site (IRES) fused to an enhanced yellow fluorescent protein (EYFP) sequence, at the 3' end of the gene. The vector also contained a loxP-flanked neomycin selection (neo) cassette. Cre-mediated recombination removed the FRT-flanked neo cassette. (J:305328)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	90 strains or lines available

Original:	J:305328 Price AE, et al., A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns. Immunity. 2018 Sep 18;49(3):560-575.e6
All:	1 reference(s)