Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Slc17a6tm1.1(flpo)Jnb
Name:	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; targeted mutation 1.1, J Nicholas Betley
MGI ID:	MGI:6156365
Synonyms:	VGlut2-IRES-FlpO
Gene:	Slc17a6  Location: Chr7:51271754-51320867 bp, + strand  Genetic Position: Chr7, 32.78 cM, cytoband B4
Alliance:	Slc17a6tm1.1(flpo)Jnb page

Germline Transmission:	Earliest citation of germline transmission: J:261454
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6J)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Slc17a6tm1.1(flpo)Jnb expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Slc17a6 (MGI:2156052)   Mutation details: The targeting vector containing a 8,572 bp genomic DNA fragment spanning exon 9-12 of mouse Slc17a6 (VGlut2) and a cassette of IRES-FlpO-loxP2272-ACE-Cre POII NeoR-loxp2272 inserted between stop codon TAA and 3' UTR was introduced into ES cells. Positive ES clones were expanded for generation of chimeric mice which have gone through self excised NeoR cassette. (J:261454)

Activity:	Tissue activity of this recombinase allele
Driver:	Slc17a6 (mouse) Summary of all recombinase alleles driven by Slc17a6. Alliance mouse Slc17a6 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc17a6 Mutation:	59 strains or lines available

Original:	J:261454 Alhadeff AL, et al., A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell. 2018 Mar 22;173(1):140-152.e15
All:	1 reference(s)