Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm2(tetO-URI1*S371A)Ndj
Name:	collagen, type I, alpha 1; targeted mutation 2, Nabil Djouder
MGI ID:	MGI:6154714
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm2(tetO-URI1*S371A)Ndj page

Germline Transmission:	Earliest citation of germline transmission: J:234982
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm2(tetO-URI1*S371A)Ndj expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human URI1 (8725) Uri1  (MGI:1342294)   Mutation details: A construct containing an FRT site, tetO sequence, FLAG tagged human URI1 cDNA containing the S371A mutation, and FRT site was inserted in KH2 ES cells. The S371A mutation generates a non-phosphorylatable form of the protein. (J:234982)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:234982 Buren S, et al., Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Cancer Cell. 2016 Aug 8;30(2):290-307
All:	1 reference(s)