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Gene Expression Data
Assay Details
Assay
Reference: J:249839 Vermeren M, et al., Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases trabecular bone mass in mice. Mamm Genome. 2017 Dec;28(11-12):498-514
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6152761
Gene symbol: Ostf1
Gene name: osteoclast stimulating factor 1
Reporter: lacZ
Direct Detection
Assay notes: It was not specified the samples were from the heterozgous or homozygous in most of the data.
Results
Specimen 2B: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: parabrachial nucleus Present 2B Highest level expression in the neurons.

Specimen 2C: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: hippocampal formation Weak 2C

Specimen 2D: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: subiculum Weak 2D

Specimen 2E: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: dentate gyrus polymorphic layer Weak 2E

Specimen 2F: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: hippocampus CA1 Absent 2F
TS28: hippocampus CA2 Weak 2F

Specimen 2G: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: hippocampus CA2 Weak 2G
TS28: hippocampus CA3 Absent 2G

Specimen 2H: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: cerebral cortex vascular element Weak 2H

Specimen 2I: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: deep cerebellar nucleus Weak Punctate 2I Expressed as small puncta in the neurons.

Specimen 2J: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: mammillary body Weak 2J
TS28: spinal vestibular nucleus Weak 2J

Specimen 2K: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: brain ventricular layer Weak 2K
TS28: choroid plexus Weak 2K
TS28: spinal vestibular nucleus Weak 2K

Specimen 2L: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Strong Regionally restricted 2L Expressed in the endothelium in large and small vessels.
TS28: meninges Present 2L Expressed in the lining of the brain, the ventricles as well as the choroid plexus.

Specimen 2M: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: brain blood vessel Strong Regionally restricted 2M Expressed in the endothelium in large and small vessels.
TS28: brain Present Regionally restricted 2M Expressed in small branched cells, presumably oligodendrocytes and their precursors, everywhere except in the cerebellum.

Specimen 2N: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: brain meninges Present 2N
TS22: chondrocranium Present 2N
TS22: head blood vessel Present 2N

Specimen 2O: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: trigeminal ganglion Strong Non-Uniform 2O

Specimen 2P: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: brain meninges Present 2P
TS22: cochlea epithelium Present 2P
TS22: cochlear ganglion Present 2P
TS22: head blood vessel Present 2P
TS22: inner ear epithelium Present 2P
TS22: spinal ganglion Strong Uniform 2P

Specimen 3A: embryonic day 11.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS18: trunk blood vessel Strong Regionally restricted 3A Expressed in the developing capillary network of the spine.
TS18: dorsal root ganglion Absent 3A

Specimen 3B: embryonic day 11.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS18: trunk blood vessel Strong Regionally restricted 3B Expressed in the developing capillary network of the spine.
TS18: dorsal root ganglion Absent 3B

Specimen 3C: embryonic day 11.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS18: trunk blood vessel Strong Regionally restricted 3C Expressed in the developing capillary network of the spine.
TS18: dorsal root ganglion Absent 3C

Specimen 3D: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: spinal cord vascular element Strong 3D
TS23: dorsal root ganglion Present 3D

Specimen 3E: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: spinal cord vascular element Strong 3E
TS23: dorsal root ganglion Present 3E

Specimen 3F: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: spinal cord vascular element Strong 3F
TS23: spinal cord lateral wall Weak Regionally restricted 3F Expressed in the motor neurons.

Specimen 3G: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: spinal cord floor plate Present 3G

Specimen 3H: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: vertebral cartilage condensation Weak Regionally restricted 3H Expressed in the cartilage surrounding the spine.

Specimen 3I: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: spinal cord vascular element Strong 3I
TS28: spinal cord dorsal column Present Regionally restricted 3I Expressed in the distal part of the dorsal funiculus.
TS28: dorsal root ganglion Present 3I Expressed in the neurites of the dorsal roots to the Dorsal Root Entry Zone.
TS28: spinal cord motor column Weak 3I

Specimen 3J: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: dorsal root ganglion Present 3J

Specimen 3K: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: spinal cord motor column Weak 3K

Specimen 3L: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: spinal cord ependymal layer Present Regionally restricted 3L Expressed in the central canal.

Specimen 3M: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: sympathetic ganglion Weak Diffuse 3M
TS28: spinal cord vascular element Strong 3M

Specimen 4A: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: retina Present Scattered 4A Expressed on the retina surface.
TS28: retina blood vessel Absent 4A
TS28: retina ganglion cell layer Present 4A

Specimen 4B: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: retina Present Scattered 4B Expressed on the retina surface.
TS28: retina blood vessel Absent 4B
TS28: retina ganglion cell layer Present 4B

Specimen 4C/D: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 4D , 4C Expressed in around cells with large nuclei and cytoplasm, presumably G1 cells.
TS28: retina blood vessel Absent 4C , 4D

Specimen 4E: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1tm1(NCOM)Cmhd (more )
Note: albino mouse
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present 4E
TS28: retina ganglion cell layer Present 4E
TS28: retina outer plexiform layer Present 4E
TS28: optic choroid Absent 4E
TS28: photoreceptor layer inner segment Absent 4E
TS28: photoreceptor layer outer segment Absent 4E
TS28: retina inner nuclear layer Absent 4E
TS28: retina inner plexiform layer Absent 4E
TS28: retina outer nuclear layer Absent 4E
TS28: sclera Absent 4E

Specimen 4F: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: retina Present Regionally restricted 4F Expressed in Muller glial cells.

Specimen 4G: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: cornea Present Regionally restricted 4G Expressed in the outer cells.
TS28: cornea epithelium Present 4G

Specimen 4I: postnatal day 6; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: eye Present Regionally restricted 4I Expressed in the capillary network.

Specimen 5A: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: bronchus epithelium Present 5A
TS28: terminal bronchus epithelium Present 5A
TS28: lung vascular element Present Regionally restricted 5A Expressed in the endothelium in both arterioles and venules.
TS28: lung alveolar parenchyma Present Regionally restricted 5A Ubiquitous expression in the respiratory epithelium.

Specimen 5B: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: lung vascular element Present Regionally restricted 5B Expressed in the developing capillary network.
TS23: bronchus Absent 5B

Specimen 5C: embryonic day 15.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS23: liver parenchyma Strong Scattered 5C Expressed in distinct cells spread in the parenchyme, likely to be hematopoietic stem cells.

Specimen 5D: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: liver Present Graded 5D Expressed exclusively in endothelial cells in a low-to high gradient from the hepatic zone 1 surrounding the portal vein to zone 3 around the central vein.

Specimen 6A: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: atrium endocardial lining Present 6A
TS28: heart blood vessel Present Regionally restricted 6A Expressed in the endothelium of the large and small vessels that form the vasa vasorum of the ventricle.
TS28: cardiac muscle tissue Weak Punctate 6A
TS28: pericardium Weak Punctate 6A

Specimen 6B: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: aortic valve Present Regionally restricted 6B Expressed at the surface of the lips.
TS22: dorsal aorta Present Regionally restricted 6B Expressed in the endothelium.

Specimen 6C: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: aortic valve Present Regionally restricted 6C Expressed at the surface of the lips.
TS22: dorsal aorta Present Regionally restricted 6C Expressed in the endothelium.
TS22: endocardial lining Absent 6C

Specimen 7A: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: renal calyx Present 7A
TS28: renal cortex Present 7A
TS28: renal medulla Present 7A
TS28: renal vasculature Present 7A
TS28: ureter Present 7A
TS28: renal fat pad Absent 7A
TS28: renal papilla Present 7A Highest expression.

Specimen 7B: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: glomerular tuft Present 7B
TS28: renal proximal convoluted tubule Present 7B

Specimen 7C: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: medullary tubule Present Widespread 7C At varying levels.
TS28: renal proximal convoluted tubule Present 7C Highest expression.

Specimen 7D: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: endothelium of renal artery Present 7D
TS28: smooth muscle layer of renal artery Present 7D

Specimen 7E: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: ureter Present 7E Expressed in the ureter wall in a mosaic of high expression patches surrounded by low expression.
TS28: renal papilla Present 7E Highest expression.

Specimen 7F: postnatal day 0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS27: metanephros Present Widespread 7F Except the outer nephrogenic zone.
TS27: adrenal gland Absent 7F
TS27: ureter Present Widespread 7F

Specimen 7G: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: developing capillary of renal cortex Present 7G
TS22: developing capillary of renal medulla Present 7G

Specimen 8A/B embryo: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1tm1(NCOM)Cmhd (more )
Structure Level Pattern Image Note
TS22: labyrinthine zone Strong 8A , 8B
TS22: spongiotrophoblast Strong 8A , 8B
TS22: trophoblast giant cell Strong 8A , 8B

Specimen 8A/B mother: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: decidua Present 8A , 8B
TS28: myometrium Present 8A , 8B

Specimen 8C: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: umbilical cord Present Regionally restricted 8C Expressed in the blood vessels.
TS22: gut Absent 8C

Specimen not shown: embryonic day 14.0; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS22: spinal cord vascular element Strong
TS22: spinal cord lateral wall Weak Regionally restricted Expressed in the motor neurons.
TS22: spinal cord floor plate Weak
TS22: dorsal root ganglion Present Regionally restricted Expressed in the sensory neurons.

Specimen not shown: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present
TS28: ventricle endocardial lining Absent

Specimen not shown: postnatal adult; Ostf1tm1(NCOM)Cmhd/Ostf1+ (more )
Note: Summarized in Table 1.
Structure Level Pattern Image Note
TS28: brain pia mater Moderate Pial surface.
TS28: amygdaloid nucleus Weak
TS28: cortical layer V Weak
TS28: dorsal cochlear nucleus Weak
TS28: medial dorsal thalamic nucleus Weak
TS28: medial vestibular nucleus Weak
TS28: oculomotor nucleus Weak
TS28: pontine nucleus Weak
TS28: pontine reticular nucleus Weak
TS28: red nucleus Weak
TS28: reticular tegmental nucleus Weak
TS28: reticular thalamic nucleus Weak
TS28: somatosensory cortex Weak
TS28: superior olivary nucleus Weak
TS28: trigeminal V sensory nucleus Weak
TS28: thalamic nucleus Weak Regionally restricted Expressed in the submedial nucleus.
TS28: dorsal raphe nucleus Strong
TS28: vestibulo-cochlear ganglion Strong
TS28: brainstem nucleus Weak Regionally restricted Nucleus of the lateral lemniscus. Moderate expression in the paragigantocellular reticular nucleus.
TS28: trigeminal ganglion Strong Uniform


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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory