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Gene Expression Data
Assay Details
Assay
Reference: J:134595 Anthony TE, et al., The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects. J Comp Neurol. 2007 Jan 10;500(2):368-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6149196
Gene symbol: Aldh1l1
Gene name: aldehyde dehydrogenase 1 family, member L1
Antibody: anti-ALDH1L1
Detection system: Secondary antibody
Results
Specimen 1A: embryonic day 9.5 (more )
Note: A TSA amplification step was used for detection.
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 1A Expression is in cells flanking the ventral midline.

Specimen 1B: embryonic day 9.5 (more )
Note: A TSA amplification step was used for detection.
Structure Level Pattern Image Note
TS15: future hindbrain Present Regionally restricted 1B Expression is in cells flanking the ventral midline.

Specimen 1C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 1C Expression is at the ventral midline.

Specimen 1D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 1D Expression is at the ventral midline.

Specimen 1E,1F: embryonic day 12.5 (more )
Note: Double labeled: red - Aldh1l1; green - Nes (assay MGI:6149221). F is a higher magnification of the center of panel E.
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 1E , 1F , 1H Expression is at the dorsal and ventral midline.

Specimen 1I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: spinal cord Present Regionally restricted 1I Expression is in radial glia.

Specimen 1J: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: tectum Present Regionally restricted 1J Expression is in the midline radial glial cells.

Specimen 1K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: hypothalamus Present Regionally restricted 1K Expression is in the midline radial glial cells.

Specimen 1L: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hypothalamus Present 1L

Specimen 2O: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cerebral cortex Present 2O Expression is throughout radial glial cell bodies and processes.

Specimen 2Q: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cerebral cortex Present 2Q Expression is throughout radial glial cell bodies and processes.

Specimen 3A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 3A Expression is in radial glia flanking the ventral and dorsal midline.

Specimen 3B: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain Present Regionally restricted 3B Expression is at the midline.
TS20: midbrain roof plate Present Regionally restricted 3B Expression is at the midline.

Specimen 3C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: caudal ganglionic eminence Present 3C

Specimen 3D: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: caudal ganglionic eminence Present 3D

Specimen 4A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted 4A Expression is in a small population of radial glia flanking the floor plate.

Specimen 4C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 4C Expression is in the ventral midline radial glia and is spreading to more dorsally located radial glia.

Specimen 4E: embryonic day 12.5 (more )
Note: Double labeled: red - Aldh1l1; green - Pax3 (assay MGI:6149225).
Structure Level Pattern Image Note
TS20: spinal cord Present 4E , 4G

Specimen 4H: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: spinal cord Strong Regionally restricted 4H Expression is in radial glia throughout the dorsoventral axis.

Specimen not shown E8.5: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo Absent

Specimen not shown E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future spinal cord Present Regionally restricted Expression is in cells flanking the ventral midline of the cervical spinal cord.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory