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Gene Expression Data
Assay Details
Assay
Reference: J:253968 Abdelhamed Z, et al., A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Development. 2018 Jan 9;145(1):dev154500
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6147580
Gene symbol: Ccdc39
Gene name: coiled-coil domain containing 39
Antibody: anti-CCDC39
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4D: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: brain Present 4D
Specimen 4E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: brain Present 4E
Specimen 4F: embryonic day 14.5; Ccdc39prh/Ccdc39prh (more )
Structure Level Pattern Image Note
TS22: brain Ambiguous 4F Authors report loss of expression - reduced to nearly undetectable levels - in mutant brains.
Specimen 4G E16.5 CCDC39: embryonic day 16.5 (more )
Note: Triple labeled: green - Ccdc39; red - Foxj1 (assay MGI:6147583); blue - DAPI.
Structure Level Pattern Image Note
TS24: brain ventricle Present Regionally restricted 4G E16.5 , 4G E16.5 CCDC39 , 4G E16.5 merged Co-expression with Foxj1 in ependhymal cells on ventromedial walls as early as E16.
Specimen 4G P0 CCDC39: postnatal day 0 (more )
Note: Triple labeled: green - Ccdc39; red - Foxj1 (assay MGI:6147583); blue - DAPI.
Structure Level Pattern Image Note
TS27: ependyma Present Regionally restricted 4G P0 , 4G P0 merged , 4G P0 CCDC39 Co-expression with Foxj1 in ependhymal cells on ventromedial walls continues through P0.
Specimen 5A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lateral ventricle choroid plexus Present Regionally restricted 5A Expression in multiciliated choroid plexus epithelium cells.
Specimen 5B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: 3rd ventricle choroid plexus Present Regionally restricted 5B Expression in multiciliated choroid plexus epithelium cells.
Specimen 5C: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lateral ventricle choroid plexus Present Regionally restricted 5C Expression in multiciliated choroid plexus epithelium cells.
TS26: cerebral aqueduct Present Regionally restricted 5C Expression in ependymal cells in the medial walls of the foramen of Monro.
Specimen 5D: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: subcommissural organ Present Regionally restricted 5D Expression in ependymal cells in the subcommissural organ.
Specimen 5E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present Regionally restricted 5E Expression in ependymal cells in the central aqueduct.
Specimen 5F CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: lateral ventricle choroid plexus Present Regionally restricted 5F Expression in multiciliated choroid plexus epithelium cells.
Specimen 5G CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: 3rd ventricle choroid plexus Present Regionally restricted 5G Expression in multiciliated choroid plexus epithelium cells.
Specimen 5H CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present Regionally restricted 5H Expression in ependymal cells in the medial walls of the foramen of Monro.
Specimen 5I CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: subcommissural organ Present Regionally restricted 5I Expression in ependymal cells in the central aqueduct.
Specimen 5J CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present Regionally restricted 5J Expression in cilia, and within ependymal cells that are not yet ciliated.
Specimen 5K LV CP CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: lateral ventricle choroid plexus Present Regionally restricted 5K LV CP CCDC39 , 5K LV CP Merged Expression in axoneme of cilia as well as in the cytoplasm.
Specimen 5K 3V CP CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: 3rd ventricle choroid plexus Present Regionally restricted 5K 3V CP Merged , 5K 3V CP CCDC39 Expression in axoneme of cilia as well as in the cytoplasm.
Specimen 5K FM EP CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present Regionally restricted 5K FM EP Merged , 5K FM EP CCDC39 Expression in axoneme of cilia as well as in the cytoplasm.
Specimen 5K SCO EP CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: subcommissural organ Present Regionally restricted 5K SCO EP Merged , 5K SCO EP CCDC39 Expression in axoneme of cilia as well as in the cytoplasm.
Specimen 5K CA EP CCDC39: embryonic day 18.5 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present Regionally restricted 5K CA EP CCDC39 , 5K CA EP Merged Expression in axoneme of cilia as well as in the cytoplasm.
Specimen S3B top left: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: 3rd ventricle choroid plexus Present S3B top left
TS26: lateral ventricle choroid plexus Present S3B top left
Specimen S3B center left: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: 3rd ventricle choroid plexus Present S3B center left
TS26: lateral ventricle choroid plexus Present S3B center left
TS26: cerebral aqueduct Present Regionally restricted S3B center left Expression in ependymal cells in ventromedial wall of foramen of Monro.
Specimen S3B bottom left: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lateral ventricle choroid plexus Present S3B bottom left
TS26: subcommissural organ Present S3B bottom left
Specimen S3B top right: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present S3B top right
Specimen S3B center right: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral aqueduct Present S3B center right
Specimen S3B bottom right: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: 4th ventricle choroid plexus Present S3B bottom right
TS26: cerebral aqueduct Present S3B bottom right
Specimen S7 WT CCDC39: postnatal day 3 (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS27: bronchus Present Regionally restricted S7_WT merged (center) , S7_WT CCDC39 , S7_WT (center)
Specimen S7 prh/prh CCDC39: postnatal day 3; Ccdc39prh/Ccdc39prh (more )
Note: Triple labeled: green - Ccdc39; red - acetylated tubulin; blue - DAPI.
Structure Level Pattern Image Note
TS27: bronchus Present Regionally restricted S7_prh/prh (center) , S7_prh/prh CCDC39 , S7_prh/prh merged (center)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory