Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cxcr1tm1Gao
Name:	C-X-C motif chemokine receptor 1; targeted mutation 1, Ji-Liang Gao
MGI ID:	MGI:6147346
Synonyms:	Cxcr1tm1Msli
Gene:	Cxcr1  Location: Chr1:74230944-74233790 bp, - strand  Genetic Position: Chr1, 38.44 cM
Alliance:	Cxcr1tm1Gao page

Germline Transmission:	Earliest citation of germline transmission: J:234122
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.7 kb neomycin resistance gene replaced 2.7 kb of the gene, which includes two thirds of the coding sequence. The deleted region starts from the middle of the third transmembrane segment predicted from the sequence (codons 121 to 351) plus 2028 base pairs of the 3' untranslated region. (J:234122)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr1 Mutation:	21 strains or lines available

Original:	J:234122 Swamydas M, et al., CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. Sci Transl Med. 2016 Jan 20;8(322):322ra10
All:	3 reference(s)