Tg(Eno2-MMP9*)EPfzr
Transgene Detail
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| Symbol: |
Tg(Eno2-MMP9*)EPfzr |
| Name: |
transgene insertion E, Jeffrey Stock |
| MGI ID: |
MGI:6144248 |
| Synonyms: |
G100L-Tg-LineE |
| Transgene: |
Tg(Eno2-MMP9*)EPfzr Location: unknown
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| Alliance: |
Tg(Eno2-MMP9*)EPfzr page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Eno2-MMP9*)EPfzr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MMP9 (4318) |
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Expresses an mutation G100L |
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Mutation details: The transgenic construct contains a rat enolase 2, gamma neuronal (Eno2) promoter, containing a random filler sequence and an SV40 polyadenylation signal, directing expression of human matrix metallopeptidase 9 (MMP9) cDNA. The MMP9 gene was modified to harbor a glycine to leucine mutation at residue 100 (MMP9*G100L), in the cysteine switch autoinhibitor region, rendering the enzyme constitutively active. Of the five lines, founder line exhibits the highest transgene activity.
(J:258077)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:258077 Fisher KE, et al., Engineering autoactivating forms of matrix metalloproteinase-9 and expression of the active enzyme in cultured cells and transgenic mouse brain. Biochemistry. 2002 Jul 2;41(26):8289-97 |
| All: |
1 reference(s) |
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Analysis Tools
