Tg(ALB-PCSK9)APfzr
Transgene Detail
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| Symbol: |
Tg(ALB-PCSK9)APfzr |
| Name: |
transgene insertion A, Jeffrey Stock |
| MGI ID: |
MGI:6144026 |
| Synonyms: |
hPCSK9 |
| Transgene: |
Tg(ALB-PCSK9)APfzr Location: unknown
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| Alliance: |
Tg(ALB-PCSK9)APfzr page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(ALB-PCSK9)APfzr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
PCSK9 (255738) |
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Mutation details: The transgenic construct contains a composite human albumin (ALB) promoter, containing a 235 bp SV40 enhancer element and a 213 bp albumin promoter element, directing expression of human proprotein convertase subtilisin/kexin type 9 (PCSK9) cDNA, followed by a C-terminal V5 tag. A chimeric intron (from pRL-SV40) was inserted between the promoter and PCSK9 cDNA to enhance expression. The transgene expresses primarily in the kidney.
(J:158079)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:158079 Luo Y, et al., Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. J Lipid Res. 2009 Aug;50(8):1581-8 |
| All: |
1 reference(s) |
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Analysis Tools
