Tg(KRT14-LMP2A)#Rlon Transgene Detail MGI Mouse (MGI:6140101)

Tg(KRT14-LMP2A)#Rlon
Transgene Detail

Summary

Symbol:	Tg(KRT14-LMP2A)#Rlon
Name:	transgene insertion, Richard Longnecker
MGI ID:	MGI:6140101
Synonyms:	K14-LMP2A
Transgene:	Tg(KRT14-LMP2A)#Rlon Location: unknown
Alliance:	Tg(KRT14-LMP2A)#Rlon page

Transgene
origin

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutation:		Insertion
		Mutation details: The human keratin 14 (KRT14) promoter drives the expression of a chimeric gene consisting of both cDNA and genomic sequences encoding latent membrane protein 2A (LMP2A) of Epsterin Barr Virus (EBV). Epithelial expression of LMP2A was demonstrated by immunoblot analysis of protein from dorsal skin of mice of transgenic line 102. Indirect immunofluorescence imaging showed expression of LMP2A and of endogenous keratin 14 to be localized to the basal level of the developing epidermis in both tail skin and tongue epithelia. (J:131112)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Southern blot analysis of genomic DNA from six transgenic lines numbered 101, 102, 103, 104, 105, and 107 demonstrated the presence of a hybridizing band of unit length 5100 derived from head-to-tail concatemers of the transgene; line 106 lacked this band, and line 108 failed to breed. Data are shown for lines 101, 102, and 107. (J:131112)

References

Original:	J:131112 Longan L, et al., Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. J Gen Virol. 2000 Sep;81(Pt 9):2245-52
All:	2 reference(s)

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