Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(CMV/tetO-Kdm2b)Atz
Name:	collagen, type I, alpha 1; targeted mutation 1, Alexandros Tzatsos
MGI ID:	MGI:6121397
Synonyms:	Tet-Kdm2b
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(CMV/tetO-Kdm2b)Atz page

Germline Transmission:	Earliest citation of germline transmission: J:232437
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(CMV/tetO-Kdm2b)Atz expresses 1 gene Knock-in expresses: Organism Expressed Gene Note Not Specified Kdm2b   Mutation details: The construct contains Kdm2b cDNA under the control of the CMV promoter fused with the tet-responsive element (tetO) which was co-electroporated into KH2 embryonic stem cells along with a plasmid expressing Flpe recombinase to allow FRT/Flpase-mediated single copy site-specific integration into the locus. (J:232437)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:232437 Andricovich J, et al., Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest. 2016 Mar 1;126(3):905-20
All:	1 reference(s)