Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Prnp-PLS3)14Ahmb
Name:	transgene insertion 14, Arthur H M Burghes
MGI ID:	MGI:6121381
Synonyms:	PrP:PLS3
Transgene:	Tg(Prnp-PLS3)14Ahmb  Location: unknown
Alliance:	Tg(Prnp-PLS3)14Ahmb page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Prnp-PLS3)14Ahmb expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PLS3 (5358) Pls3  (MGI:104807)   Mutation details: The transgenic construct contains the regulatory sequences from mouse prion protein gene (the promoter region, exon 1, intron 1 and part of exon 2) followed by a cDNA encoding the human plastin 3 protein and two SV40 polyA signals. (J:238311)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:238311 McGovern VL, et al., Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the 7 SMA Mouse. PLoS One. 2015;10(7):e0132364
All:	1 reference(s)