Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Asic4tm1.1(cre/ERT2)Cibms
Name:	acid-sensing ion channel family member 4; targeted mutation 1.1, Chih-Cheng Chen
MGI ID:	MGI:6120518
Synonyms:	Asic4-, Asic4CreERT2, ASIC4-KO/CreERT2
Gene:	Asic4  Location: Chr1:75427080-75450987 bp, + strand  Genetic Position: Chr1, 39.08 cM
Alliance:	Asic4tm1.1(cre/ERT2)Cibms page

Germline Transmission:	Earliest citation of germline transmission: J:253311
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Asic4tm1.1(cre/ERT2)Cibms expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Asic4 (MGI:2652846)   Mutation details: Thetargeting vector was constructed with the cre/ERT2 gene knocked into the initiator methionine of mouse ASIC4 to replace first 267 amino acid peptides in the N-terminus of ASIC4. A pGK-neo selection cassette flanked by loxP sites was placed downstream of the polyadenylation signal of cre/ERT2. The floxed-pGK-neo cassette was removed by crossing with cre expressing mice. It is a null allele. (J:253311)

Activity:	Tissue activity of this recombinase allele
Driver:	Asic4 (mouse) Summary of all recombinase alleles driven by Asic4. Alliance mouse Asic4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Asic4 Mutation:	28 strains or lines available

Original:	J:253311 Lin SH, et al., Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci. 2015 Jun;41(12):1553-68
All:	1 reference(s)