Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(tetO-Pdx1,-Mafa,-Neurog3,-GFP)Stang
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ben Stanger
MGI ID:	MGI:6120506
Synonyms:	R26Tetbeta
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(tetO-Pdx1,-Mafa,-Neurog3,-GFP)Stang page

Germline Transmission:	Earliest citation of germline transmission: J:211832
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, Reporter) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Gt(ROSA)26Sortm1(tetO-Pdx1,-Mafa,-Neurog3,-GFP)Stang expresses 3 genes Knock-in expresses: Organism Expressed Gene Note mouse Mafa (MGI:2673307) mouse Neurog3 (MGI:893591) mouse Pdx1 (MGI:102851)   Mutation details: The targeting construct contains (3' to 5'): loxP site, PGK-neo, loxP site, tetO, Pdx1 cDNA, T2A sequence, Mafa cDNA, P2A sequence, Neurog cDNA, P2A sequence, HIST1H2BJ/GFP cDNA. (J:211832)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:211832 Chen YJ, et al., De novo formation of insulin-producing "neo-beta cell islets" from intestinal crypts. Cell Rep. 2014 Mar 27;6(6):1046-58
All:	1 reference(s)