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Gene Expression Data
Assay Details
Assay
Reference: J:235223 Omori H, et al., Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS Lett. 2016 Aug;590(16):2584-93
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6119679
Gene symbol: C2cd4c
Gene name: C2 calcium-dependent domain containing 4C
Reporter: lacZ
Direct Detection
Results
Specimen 3A top left: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Pdx1 (assay MGI:6119684).
Structure Level Pattern Image Note
TS22: pancreas trunk epithelium Present 3A S-Gal/Pdx1 Expression overlapped with Pdx1-positive (endocrine progenitor) cells.
Specimen 3A top center: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Nkx6-1 (assay MGI:6119685).
Structure Level Pattern Image Note
TS22: pancreas epithelium Present 3A S-Gal/Nkx6.1 Some S-Gal stained cells also expressed Nkx6.1 (endocrine progenitor) cells.
Specimen 3A top right: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Neurog3 (assay MGI:6119686).
Structure Level Pattern Image Note
TS22: pancreas epithelium Present 3A S-Gal/Ngn3 Some S-Gal stained cells also expressed Neurog3 (endocrine progenitor) cells.
Specimen 3A bottom left: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Ins1 (assay MGI:6119687) and Ins2 (assay MGI:6119688).
Structure Level Pattern Image Note
TS22: pancreas epithelium Present 3A S-Gal/Ins Expression overlapped with Insulin-positive (endocrine progenitor) cells.
Specimen 3A bottom center: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Gcg (assay MGI:6119689).
Structure Level Pattern Image Note
TS22: pancreas epithelium Present 3A S-Gal/Gcg Expression overlapped with Gcg-positive (endocrine progenitor) cells.
Specimen 3A bottom right: embryonic day 14.5; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Amy (assay MGI:6119691).
Structure Level Pattern Image Note
TS22: pancreas epithelium Present 3A S-Gal/Amy
TS22: pancreatic acinus Absent 3A S-Gal/Amy Staining did not overlap with amylase-expressing acinar cells (exocrine).
Specimen 3C top left: postnatal adult; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Ins1 (assay MGI:6119687) and Ins2 (assay MGI:6119688).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3C S-Gal/Ins Staining overlapped with Insulin-positive beta cells in the islets.
Specimen 3C top left center: postnatal adult; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Gcg (assay MGI:6119689).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3C S-Gal/Gcg Staining was noted in islets and did not overlap with Gcg.
Specimen 3C top right center: postnatal adult; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Sst (assay MGI:6119700).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3C S-Gal/Sst Staining was noted in islets and did not overlap with Sst.
Specimen 3C top right: postnatal adult; C2cd4ctm1(KOMP)Mbp/C2cd4c+ (more )
Note: Double labeled: blue - C2cd4c; red - Ppy (assay MGI:6119701).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 3C S-Gal/PP Staining was noted in islets and did not overlap with Ppy.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory