Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gfra1tm1.1(cre/ERT2)Cfi
Name:	glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, Carlos F Ibanez
MGI ID:	MGI:6119532
Synonyms:	Gfra1CreERT2
Gene:	Gfra1  Location: Chr19:58224036-58444341 bp, - strand  Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
Alliance:	Gfra1tm1.1(cre/ERT2)Cfi page

Germline Transmission:	Earliest citation of germline transmission: J:251552
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gfra1tm1.1(cre/ERT2)Cfi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gfra1 (MGI:1100842)   Mutation details: The targeting vector using bacterial artificial chromosomes (BACs) from the C57BL/6J RPCIB-731 BAC library was constructed by inserting a CreERT2 cassette and F3 flanked puromycin resistant cassette into the second exon of the Gfra1 gene in frame. The vector was transfected into the TaconicArtemis C57BL/6N Tac ESC line to establish mouse line by homologous recombination. Flp-mediated recombination removed the F3-flanked puro cassette. (J:251552)

Activity:	Tissue activity of this recombinase allele
Driver:	Gfra1 (mouse) Summary of all recombinase alleles driven by Gfra1. Alliance mouse Gfra1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra1 Mutation:	31 strains or lines available

Original:	J:251552 Sergaki MC, et al., GFRalpha1 Regulates Purkinje Cell Migration by Counteracting NCAM Function. Cell Rep. 2017 Jan 10;18(2):367-379
All:	3 reference(s)