Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Cacng5-cre)181Tjmc
Name:	transgene insertion 181, Thomas J McHugh
MGI ID:	MGI:6117425
Synonyms:	Cacng5-Cre
Transgene:	Tg(Cacng5-cre)181Tjmc  Location: unknown
Alliance:	Tg(Cacng5-cre)181Tjmc page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Cacng5-cre)181Tjmc expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Cacng5 (MGI:2157946)   Mutation details: The bacterial artificial chromosome (BAC) RP23-145G23 containing mouse calcium channel, voltagedependent, gamma subunit 5 (Cacng5) gene was modified to insert a Cre-FRT-Amp-FRT cassette at the start site of Cacng5 translation. The ampicillin (Amp) marker was deleted and the Cre-modified BAC's were confirmed, purified and injected into C57BL/6 fertilized pronuclei. Five founders (lines 160, 181, 190, 212, 225) were generated. The 181 Cacng5-Cre line was determined to express Cre selectively in the CA2 area of hippocampus using immunohistochemistry with the anti-Cre antibody, and used for analyses. (J:256034)

Activity:	Tissue activity of this recombinase allele
Driver:	Cacng5 (mouse) Summary of all recombinase alleles driven by Cacng5. Comparative matrix view of recombinase activities Alliance mouse Cacng5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:256034 Boehringer R, et al., Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability. Neuron. 2017 May 3;94(3):642-655.e9
All:	4 reference(s)