Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Cdh4tm1.1(cre/ERT2)Jrs
Name:	cadherin 4; targeted mutation 1.1, Joshua R Sanes
MGI ID:	MGI:6116670
Synonyms:	Cdh4CreER
Gene:	Cdh4  Location: Chr2:179084228-179541166 bp, + strand  Genetic Position: Chr2, 101.86 cM
Alliance:	Cdh4tm1.1(cre/ERT2)Jrs page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Cdh4tm1.1(cre/ERT2)Jrs expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cdh4 (MGI:99218)   Mutation details: The targeting vector consisting of a FRT flanked neo cassette, a 6xmyc-tagged CreER-T2, and poly-adenylation signal replaced N-term 19 amino acid at the translational start site of the mouse Cdh4 via homologous recombination. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:235958)

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh4 (mouse) Summary of all recombinase alleles driven by Cdh4. Alliance mouse Cdh4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh4 Mutation:	56 strains or lines available

Original:	J:235958 Rousso DL, et al., Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44
All:	3 reference(s)