Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(tetO-Yap1*,-GFP*)Stang
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ben Stanger
MGI ID:	MGI:6115248
Synonyms:	tetO-YAP-GFP
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(tetO-Yap1*,-GFP*)Stang page

Germline Transmission:	Earliest citation of germline transmission: J:255620
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, Reporter) Inducer:    doxycycline/tetracycline Mutations:    Insertion, Nucleotide substitutions   Mutation details: The targeting vector contains a loxP site flanked PGK-neo cassette, a mutant mouse Yap1 gene (with an amino acid substitution of serine-to-alanine at position 112), viral 2A peptide sequence, HIST1H2BJ/GFP (H2B-GFP) cDNA, beta-globin and polyadenylation sequence, under the control of the tetO, tetracycline-responsive regulatory element (TRE-tight). (J:255620)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	944 strains or lines available

Original:	J:255620 Gao T, et al., Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1
All:	4 reference(s)