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Tg(Pcp2-ATXN1*82Q)R2Horr
Transgene Detail
Summary
Symbol: Tg(Pcp2-ATXN1*82Q)R2Horr
Name: transgene insertion R2, Harry T Orr
MGI ID: MGI:6113813
Transgene: Tg(Pcp2-ATXN1*82Q)R2Horr  Location: unknown  
Alliance: Tg(Pcp2-ATXN1*82Q)R2Horr page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pcp2-ATXN1*82Q)R2Horr expresses 1 gene
 
Tg(Pcp2-ATXN1*82Q)R2Horr expression driven by 1 gene
 
Mutation detailsThe transgene consists of a mouse Pcp2 promoter and a human mutant SCA1 cDNA sequence with 82 CAG repeats. The 835 bp fragment of mouse Pcp2 regulatory sequence include exon 1, intron 1, and part of exon 2 of Pcp2. The Pcp2 promoter targets transgene expression to Purkinje cells. Line R2 was generated. (J:261279)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:261279 Rousseaux MWC, et al., ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. 2018 Mar 21;97(6):1235-1243.e5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory