Tg(Pcp2-ATXN1*82Q)R2Horr
Transgene Detail
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| Symbol: |
Tg(Pcp2-ATXN1*82Q)R2Horr |
| Name: |
transgene insertion R2, Harry T Orr |
| MGI ID: |
MGI:6113813 |
| Transgene: |
Tg(Pcp2-ATXN1*82Q)R2Horr Location: unknown
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| Alliance: |
Tg(Pcp2-ATXN1*82Q)R2Horr page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Pcp2-ATXN1*82Q)R2Horr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
ATXN1 (6310) |
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expresses a human mutant cDNA sequence with 82 CAG repeats |
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Tg(Pcp2-ATXN1*82Q)R2Horr expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Pcp2 (MGI:97508) |
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Mutation details: The transgene consists of a mouse Pcp2 promoter and a human mutant SCA1 cDNA sequence with 82 CAG repeats. The 835 bp fragment of mouse Pcp2 regulatory sequence include exon 1, intron 1, and part of exon 2 of Pcp2. The Pcp2 promoter targets transgene expression to Purkinje cells. Line R2 was generated.
(J:261279)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:261279 Rousseaux MWC, et al., ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. 2018 Mar 21;97(6):1235-1243.e5 |
| All: |
2 reference(s) |
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Analysis Tools
