Tg(RP23-159N6*)23Bdm
Transgene Detail
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| Symbol: |
Tg(RP23-159N6*)23Bdm |
| Name: |
transgene insertion 23, Bernard de Massy |
| MGI ID: |
MGI:5565212 |
| Synonyms: |
Tg(Prdm9wm7*Y357F) |
| Transgene: |
Tg(RP23-159N6*)23Bdm Location: unknown
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| Alliance: |
Tg(RP23-159N6*)23Bdm page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgenic construct was derived from that used for Tg(RP23-159N6*)43Bdm, in which the sequence encoding the zinc finger domain of Prdm9 in the C57BL/6J-derived mouse bacterial artificial chromosome (BAC) RP23-159N6 was replaced by the corresponding segment from the Prdm9wm7 allele of strain B10.A(R209)-H2aw9. The present transgene has been further modified by mutation of codons 357-358 from TATGGG to TTTGGT to give rise to a mutant PRDM9 protein in which tyrosine has been replaced by phenylalanine at amino acid position 357 (Y357F).
(J:255344)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:255344 Diagouraga B, et al., PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites. Mol Cell. 2018 Mar 1;69(5):853-865.e6 |
| All: |
4 reference(s) |
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Analysis Tools
