AU040320tm1d(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
AU040320tm1d(EUCOMM)Wtsi |
Name: |
expressed sequence AU040320; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6111781 |
Synonyms: |
AU040320-Null |
Gene: |
AU040320 Location: Chr4:126647331-126763487 bp, + strand Genetic Position: Chr4, 60.94 cM
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Alliance: |
AU040320tm1d(EUCOMM)Wtsi page
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IMPC: |
AU040320 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:249823
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 126685053 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 126686435. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s).
(J:249823)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any AU040320 Mutation: |
58 strains or lines available
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Original: |
J:249823 Guidi LG, et al., Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319 and KIAA0319L have Unaffected Neuronal Migration but Display Abnormal Auditory Processing. Cereb Cortex. 2017 Dec 1;27(12):5831-5845 |
All: |
1 reference(s) |
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