Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Wdr47tm1b(EUCOMM)Wtsi
Name:	WD repeat domain 47; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID:	MGI:6102912
Gene:	Wdr47  Location: Chr3:108498595-108553035 bp, + strand  Genetic Position: Chr3, 47.38 cM
Alliance:	Wdr47tm1b(EUCOMM)Wtsi page
IMPC:	Wdr47 gene page

Mutant Cell Line:	EPD0046_1_C04
Germline Transmission:	Earliest citation of germline transmission: J:249035
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_gt0   Mutation details: The L1L2_gt0 cassette was inserted at position 108525343 of Chromosome 3 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 108526974. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:249035)

In Mice Carrying this Mutation:

23 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdr47 Mutation:	53 strains or lines available

Original:	J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317
All:	2 reference(s)