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Gene Expression Data
Assay Details
Assay
Reference: J:120961 Adam J, et al., A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst). 2007 Feb 4;6(2):224-34
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6099049
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 4A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: forebrain Absent 4A
Specimen 4B: embryonic day 12.5; Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain Present 4B On average 30-50% of cells were undergoing apoptosis in specific regions of the forebrain.
Specimen 4C: embryonic day 12.5; Trp53tm1Brd/Trp53tm1Brd, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain Absent 4C
Specimen 4D: embryonic day 12.5; Trp53tm1Brd/Trp53+, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain Absent 4D
Specimen 4E: embryonic day 12.5; Atmtm1Led/Atmtm1Led, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain Present 4E
Specimen 4G: embryonic day 12.5; Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain ventricular layer Present 4G
TS20: forebrain Present Regionally restricted 4G Apoptotic cells were noted within the neuroepithelium layers (e.g. ventricular zone and primordial plexiform layer).
Specimen 4H: embryonic day 12.5; Atmtm1Led/Atmtm1Led, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS20: forebrain ventricular layer Present 4H
TS20: forebrain Present Regionally restricted 4H Apoptotic cells were noted within the neuroepithelium layers (e.g. ventricular zone and primordial plexiform layer).
Specimen 5A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: head mesenchyme Absent 5A
Specimen 5B: embryonic day 9.5; Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: head mesenchyme Present 5B Apoptosis was found to occur in 20-40% of cells in the mesenchyme.
Specimen 5C: embryonic day 9.5; Trp53tm1Brd/Trp53tm1Brd, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: head mesenchyme Absent 5C
Specimen 5D: embryonic day 9.5; Trp53tm1Brd/Trp53+, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: head mesenchyme Absent 5D
Specimen 5E: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: tail somite Absent 5E
Specimen 5F: embryonic day 9.5; Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: tail somite Present 5F Apoptosis was found to occur in 20-40% of cells in the pairs of somites laterally positioned to the caudal neural tube.
Specimen 5G: embryonic day 9.5; Trp53tm1Brd/Trp53tm1Brd, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: tail somite Absent 5G
Specimen 5H: embryonic day 9.5; Trp53tm1Brd/Trp53+, Xrcc2tm1Jtk/Xrcc2tm1Jtk (more )
Structure Level Pattern Image Note
TS15: tail somite Absent 5H
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory