Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CD3E)22Alat
Name:	transgene insertion 22, Alan Tunnacliffe
MGI ID:	MGI:6098740
Synonyms:	hCD3epsilon TG22
Transgene:	Tg(CD3E)22Alat  Location: unknown
Alliance:	Tg(CD3E)22Alat page

Strain of Origin:

(C57BL/6 x DBA/2)F2

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CD3E)22Alat expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CD3E (916) Cd3e  (MGI:88332)   Mutation details: Human cosmid cEpsilon1, containing the CD3E gene, was injected into BDF2 fertilized oocytes. Five independent lines were established: three low copy and two high copy number. This allele represents a high copy number with approximately 40 transgene insertions. Northern blot analysis showed that the human gene was expressed in the correct T cell-specific manner. (J:172562)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:249821 Tunnacliffe A, et al., The majority of human CD3 epitopes are conferred by the epsilon chain. Int Immunol. 1989;1(5):546-50
All:	2 reference(s)