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Gene Expression Data
Assay Details
Assay
Reference: J:127109 Schnichels S, et al., Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J. Gene Expr Patterns. 2007 Dec;8(1):1-11
Assay type: RNA in situ
MGI Accession ID: MGI:6098710
Gene symbol: Rgma
Gene name: repulsive guidance molecule family member A
Probe: Rgma probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 14.5 (more )
Note: Authors state there were no differences in the expression pattern in the developing retina between C57BL/6J and DBA/2J mice (E14.5, P0 and P10) (data not shown).
Structure Level Pattern Image Note
TS22: eye Absent 1A No expression detected in embryonic mouse eye.
Specimen 1B: postnatal day 0 (more )
Note: Authors state there were no differences in the expression pattern in the developing retina between C57BL/6J and DBA/2J mice (E14.5, P0 and P10) (data not shown).
Structure Level Pattern Image Note
TS27: retina layer Present Regionally restricted 1B Author report expression in every layer of the developing retina except for inner plexiform layer.
TS27: retina inner plexiform layer Absent 1B
Specimen 1C: postnatal day 10 (more )
Note: Authors state there were no differences in the expression pattern in the developing retina between C57BL/6J and DBA/2J mice (E14.5, P0 and P10) (data not shown).
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 1C
TS28: retina inner nuclear layer Present 1C
TS28: retina outer nuclear layer Strong Regionally restricted 1C Higher expression localized near outer border of outer nuclear layer (probably cones).
Specimen 4A: postnatal month 3 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 4A
TS28: retina inner nuclear layer Present 4A
TS28: retina outer nuclear layer Present 4A
Specimen 4B: postnatal month 3 (more )
Note: DBA/2J mice not yet affected by glaucoma.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 4B Expression in ganglion cell layer, inner nuclear layer and outer nuclear layer was stronger in DBA/2J than in C57BL/6J mice.
TS28: retina inner nuclear layer Strong 4B Expression in ganglion cell layer, inner nuclear layer and outer nuclear layer was stronger in DBA/2J than in C57BL/6J mice.
TS28: retina outer nuclear layer Strong 4B Expression in ganglion cell layer, inner nuclear layer and outer nuclear layer was stronger in DBA/2J than in C57BL/6J mice.
Specimen 4C: postnatal month 3 (more )
Note: DBA/2J mice affected by glaucoma.
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 4C Authors report a difference in expression intensity in mice not yet affected by glaucoma (4B) and those that already were (4C).
TS28: retina inner nuclear layer Present 4C Authors report a difference in expression intensity in mice not yet affected by glaucoma (4B) and those that already were (4C).
TS28: retina outer nuclear layer Present 4C Authors report a difference in expression intensity in mice not yet affected by glaucoma (4B) and those that already were (4C).
Specimen 4D: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: retina Weak 4D Weaker expression in C57BL/6J than in DBA/2J mice.
Specimen 4E: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: retina Present 4E
Specimen 4F: postnatal month 15 (more )
Structure Level Pattern Image Note
TS28: retina Weak 4F Weaker expression in C57BL/6J than in DBA/2J mice.
Specimen 4G: postnatal month 15 (more )
Structure Level Pattern Image Note
TS28: retina Present 4G
Specimen 6A: postnatal month 3 (more )
Structure Level Pattern Image Note
TS28: retina Present Regionally restricted 6A Authors report congruent expression pattern of Rgma and neogenin.
Specimen 8A: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present 8A No significant difference in expression between C57BL/6J and DBA/2J mice.
Specimen 8B: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present 8B No significant difference in expression between C57BL/6J and DBA/2J mice.
Specimen 8C: postnatal month 11 (more )
Structure Level Pattern Image Note
TS28: optic nerve Weak 8C Lower expression compared with younger C57BL/6J mice.
Specimen 8D: postnatal month 11 (more )
Structure Level Pattern Image Note
TS28: optic nerve Strong 8D Expression increased almost 3-times higher than DBA/2J mice at 6 months.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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