Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Actb-Nfe2l2,-EGFP)1Swnr
Name:	transgene insertion 1, Sabine Werner
MGI ID:	MGI:6095167
Synonyms:	betaACTcaNrf2
Transgene:	Tg(Actb-Nfe2l2,-EGFP)1Swnr  Location: unknown
Alliance:	Tg(Actb-Nfe2l2,-EGFP)1Swnr page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence, Modified isoform(s), Reporter) Mutation:    Insertion   Mutation details: The transgene comprises the following elements: a beta-actin promoter, a loxP site flanked STOP cassette, the cDNA for the constitutively active isoform of the mouse Nfe2l2 gene which lacks sequence for the N-terminal Neh2 domain, an internal ribosomal entry site (IRES), and the EGFP fluorescent reporter gene. This is line 1 of five mouse lines with different integration sites that were established after pronuclear injection of FVB/N fertilized oocytes. The mouse gene (and the reporter) will only be expressed after deletion of the STOP cassette through Cre-mediated recombination. (J:160519)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:160519 Schafer M, et al., Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev. 2010 May 15;24(10):1045-58
All:	1 reference(s)