Tg(Actb-Nfe2l2,-EGFP)CMVSwnr
Transgene Detail
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| Symbol: |
Tg(Actb-Nfe2l2,-EGFP)CMVSwnr |
| Name: |
transgene insertion CMV, Sabine Werner |
| MGI ID: |
MGI:6095171 |
| Synonyms: |
CMVcaNrf2 |
| Transgene: |
Tg(Actb-Nfe2l2,-EGFP)CMVSwnr Location: unknown
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| Alliance: |
Tg(Actb-Nfe2l2,-EGFP)CMVSwnr page
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| Transgene Type: |
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Transgenic (Conditional ready, Constitutively active, Inserted expressed sequence, Modified isoform(s), Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene is derived from the Tg(CMV-SALL4_iB)#Chai allele and comprises the following elements: the CMV early enhancer a beta-actin promoter, a loxP site flanked STOP cassette, the cDNA for the constitutively active isoform of the mouse Nfe2l2 gene which lacks sequence for the N-terminal Neh2 domain, an internal ribosomal entry site (IRES), and the EGFP fluorescent reporter gene. The construct was injected into the proneclei of FVB/N fertilized oocytes. The mouse gene (and the reporter) will only be expressed after deletion of the STOP cassette through Cre-mediated recombination.
(J:248498)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:248498 Schafer M, et al., Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med. 2012 May;4(5):364-79 |
| All: |
5 reference(s) |
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Analysis Tools
