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Gene Expression Data
Assay Details
Assay
Reference: J:88451 Mori M, et al., Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium. Am J Pathol. 2004 Feb;164(2):701-10
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6094884
Gene symbol: Rpe65
Gene name: retinal pigment epithelium 65
Antibody: anti-RPE65
Detection system: Secondary antibody
Assay notes: TRP1-Cre (tg/0)/RXR +/+ and TRP1-Cre (0/0)/RXR L2/L2 littermates were also used as controls.
Results
Specimen E17.5 control not shown: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: pigmented retinal epithelium Absent
Specimen E17.5 rpe-/- not shown: embryonic day 17.5; Rxratm4Ipc/Rxratm4Ipc, Tg(Tyrp1-cre)1Ipc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS25: pigmented retinal epithelium Absent
Specimen P4 control not shown: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Absent
Specimen P4 rpe-/- not shown: postnatal day 4; Rxratm4Ipc/Rxratm4Ipc, Tg(Tyrp1-cre)1Ipc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Absent
Specimen 6j: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present 6j
Specimen 6n: postnatal month 6; Rxratm4Ipc/Rxratm4Ipc, Tg(Tyrp1-cre)1Ipc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Weak Regionally restricted 6n Authors state expression was weak or absent in some regions of retinal pigment epithelium.
Specimen 6l: postnatal month 6 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present 6l
Specimen 6p: postnatal month 6; Rxratm4Ipc/Rxratm4Ipc, Tg(Tyrp1-cre)1Ipc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Weak Regionally restricted 6p Authors state expression was weak or absent in some regions of retinal pigment epithelium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory