Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spata2em1Jliu
Name:	spermatogenesis associated 2; endonuclease-mediated mutation 1, Jiali Liu
MGI ID:	MGI:6093706
Gene:	Spata2  Location: Chr2:167323053-167334804 bp, - strand  Genetic Position: Chr2, 87.23 cM
Alliance:	Spata2em1Jliu page

Strain of Origin:

ICR

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: CRISPR/Cas9 technology targeting exon 2 results in an 1009 bp deletion from the 83 bp after the initiation codon to the 199th base of exon 3. Western blot analysis confirmed the absence of protein expression in testis. (J:247929)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spata2 Mutation:	20 strains or lines available

Original:	J:247929 Zhao J, et al., Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice. Biol Reprod. 2017 Sep 01;97(3):497-513
All:	1 reference(s)