Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tac2tm1.1(cre)Mgmj
Name:	tachykinin 2; targeted mutation 1.1, Martin G Myers, Jr
MGI ID:	MGI:5911624
Synonyms:	Tac2cre
Gene:	Tac2  Location: Chr10:127560347-127567637 bp, + strand  Genetic Position: Chr10, 74.81 cM, cytoband D3
Alliance:	Tac2tm1.1(cre)Mgmj page

Germline Transmission:	Earliest citation of germline transmission: J:234023
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Tac2tm1.1(cre)Mgmj expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tac2 (MGI:98476)   Mutation details: An Frt-neo-Frt-IRES-cre cassette was inserted between the stop codon and polyA site of the Tac2 gene by homologous recombination in R1 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice, and then bred to a line expressing Flp recombinase to remove the Frt-flanked neo cassette. (J:234023)

Activity:	Tissue activity of this recombinase allele
Driver:	Tac2 (mouse) Summary of all recombinase alleles driven by Tac2. Alliance mouse Tac2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tac2 Mutation:	18 strains or lines available

Original:	J:234023 Greenwald-Yarnell ML, et al., ERalpha in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology. 2016 Apr;157(4):1555-65
All:	1 reference(s)