Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Kiss1tm1.1(cre)Mgmj
Name:	KiSS-1 metastasis-suppressor; targeted mutation 1.1, Martin G Myers, Jr
MGI ID:	MGI:5911623
Synonyms:	Kiss1cre
Gene:	Kiss1  Location: Chr1:133254950-133257460 bp, + strand  Genetic Position: Chr1, 57.91 cM
Alliance:	Kiss1tm1.1(cre)Mgmj page

Germline Transmission:	Earliest citation of germline transmission: J:234023
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Kiss1tm1.1(cre)Mgmj expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Kiss1 (MGI:2663985)   Mutation details: An Frt-neo-Frt-IRES-cre cassette was inserted between the stop codon and polyA site of the Kiss1 gene by homologous recombination in R1 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice, and then bred to a line expressing Flp recombinase to remove the Frt-flanked neo cassette. (J:234023)

Activity:	Tissue activity of this recombinase allele
Driver:	Kiss1 (mouse) Summary of all recombinase alleles driven by Kiss1. Alliance mouse Kiss1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1 Mutation:	21 strains or lines available

Original:	J:234023 Greenwald-Yarnell ML, et al., ERalpha in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology. 2016 Apr;157(4):1555-65
All:	3 reference(s)