Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc
Transgene Detail
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| Symbol: |
Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc |
| Name: |
transgene insertion 16, Centro Nacional de Biotecnologia |
| MGI ID: |
MGI:5910352 |
| Transgene: |
Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc Location: unknown
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| Alliance: |
Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc page
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| Strain of Origin: |
(C57BL/6 CBA)F1
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| Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
KCNIP3 (30818) |
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mutated EFhand domains 2, 3 and 4 |
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Mutation details: The cDNA encoding human KCNIP3 (DREAM) with two amino-acid substitutions each at EFhands 2, 3 and 4 (EFmDREAM) was inserted downstream of the human CaMKII promoter. The cDNA was followed by an IRES and the LacZ reporter gene. The amino acid substitutions rendered the mutant insensitive to Ca2+, and thus can block the Ca2+dependent derepression function of DREAM and other KChIP proteins endogenously expressed.
(J:103733)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:103733 Savignac M, et al., Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression. EMBO J. 2005 Oct 19;24(20):3555-64 |
| All: |
4 reference(s) |
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Analysis Tools
