Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Elmo1tm1Mki
Name:	engulfment and cell motility 1; targeted mutation 1, Masao Kakoki
MGI ID:	MGI:5910335
Synonyms:	Elmo1L
Gene:	Elmo1  Location: Chr13:20274766-20792523 bp, + strand  Genetic Position: Chr13, 7.21 cM, cytoband A3.1
Alliance:	Elmo1tm1Mki page

Germline Transmission:	Earliest citation of germline transmission: J:230491
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3'UTR was replaced with A loxP site, unstbale mouse Fos 3'UTR, neomycin resistance cassette, loxP site and stable bovine GH 3'UTR. QRT-PCR confirmed reduced transcript expression in the kidney of 40 week old mice. (J:230491)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Elmo1 Mutation:	58 strains or lines available

Original:	J:230491 Hathaway CK, et al., High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2218-22
All:	4 reference(s)