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Gene Expression Data
Assay Details
Assay
Reference: J:171311 Haupt C, et al., Adenylate Cyclase 1 modulates peripheral nerve branching patterns. Mol Cell Neurosci. 2010 Dec;45(4):439-48
Assay type: RNA in situ
MGI Accession ID: MGI:5909061
Gene symbol: Adcy1
Gene name: adenylate cyclase 1
Probe: clone IRAKp961E0199Q2
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: Tissues were either fresh frozen or fixed in 4% paraformaldehyde.
Results
Specimen 1B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Weak 1B' , 1B
TS19: future spinal cord Weak 1B' , 1B
Specimen 1D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord ventral horn Present 1D , 1D'
TS20: spinal cord Present Regionally restricted 1D Expression is in a small population of cells adjacent to the roof plate.
TS20: dorsal root ganglion Present Regionally restricted 1D , 1D' Expression is in a subpopulation.
Specimen 1F: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Strong 1F , 1F'
TS21: spinal cord ventral horn Strong 1F , 1F'
TS21: spinal cord Strong Regionally restricted 1F , 1F' Expression is in a small population of cells adjacent to the roof plate.
Specimen 1H: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Strong 1H , 1H'
TS22: spinal cord ventral horn Strong 1H , 1H'
TS22: spinal cord Strong Regionally restricted 1H , 1H' Expression is in a small population of cells adjacent to the roof plate.
Specimen 1J: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: dorsal root ganglion Strong 1J' , 1J
TS23: spinal cord ventral horn Strong 1J' , 1J
TS23: spinal cord dorsal horn Strong 1J
TS23: spinal cord Strong Scattered 1J' , 1J
Specimen 2A: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: spinal cord Present Regionally restricted 2A Expression is adjacent to the roof plate.
TS27: dorsal root ganglion Present Regionally restricted 2A , 2C Expression is in a subpopulation of sensory neurons.
TS27: spinal cord ventral horn Weak Regionally restricted 2B , 2A Expression is in motor neurons.
Specimen 3A: embryonic day 13.5 (more )
Note: Brachial level of the spinal cord. Triple labeled: precipitate - Adcy1; green - Isl1 (assay MGI:5909094 and Isl2 (assay MGI:5909412); red - Lhx1 (assay MGI:5909099).
Structure Level Pattern Image Note
TS21: spinal cord ventral horn Strong Regionally restricted 3D , 3A Expression is in neurons of the medial aspect of the lateral motor column that project into the ventral limb and in the lateral neurons of the medial motor column.
Specimen 3F: embryonic day 13.5 (more )
Note: Thoracic level of the spinal cord. Triple labeled: precipitate - Adcy1; green - Isl1 (assay MGI:5909094 and Isl2 (assay MGI:5909412); red - Lhx1 (assay MGI:5909099).
Structure Level Pattern Image Note
TS21: spinal cord ventral horn Strong Regionally restricted 3I , 3F Expression is in neurons of the medial aspect of the lateral motor column that project into the ventral limb and in the lateral neurons of the medial motor column.
Specimen 3K: embryonic day 13.5 (more )
Note: Lumbar level of the spinal cord. Triple labeled: precipitate - Adcy1; green - Isl1 (assay MGI:5909094 and Isl2 (assay MGI:5909412); red - Lhx1 (assay MGI:5909099).
Structure Level Pattern Image Note
TS21: spinal cord ventral horn Strong Regionally restricted 3N , 3K Expression is in neurons of the medial aspect of the lateral motor column that project into the ventral limb and is very weak in the lateral neurons of the medial motor column.
Specimen 4A: embryonic day 13.5 (more )
Note: Double labeled: precipitate - Adcy1; green- Isl1 (assay MGI:5909094) and Isl2 (assay MGI:5909412).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present Regionally restricted 4C , 4A , 4C'
Specimen 4D: embryonic day 13.5 (more )
Note: Triple labeled: precipitate - Adcy1; green - Ntrk1 (assay MGI:5909133); red - Ntrk3 (assay MGI:5909134).
Structure Level Pattern Image Note
TS21: dorsal root ganglion Present Regionally restricted 4D , 4E' , 4E'' , 4G , 4F'' , 4F'
Specimen Table 1 E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: dorsal root ganglion Absent
TS17: future spinal cord Absent
Specimen Table 1 E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Weak
TS19: future spinal cord Weak
Specimen Table 1 E12: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Moderate
TS20: spinal cord ventral horn Moderate
TS20: spinal cord dorsal horn Weak
TS20: spinal cord roof plate Weak
Specimen Table 1 E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: dorsal root ganglion Strong
TS20: spinal cord dorsal horn Strong
TS20: spinal cord roof plate Strong
TS20: spinal cord ventral horn Strong
Specimen Table 1 E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Strong
TS21: spinal cord ventral horn Strong
TS21: spinal cord dorsal horn Moderate
TS21: spinal cord roof plate Moderate
Specimen Table 1 E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: dorsal root ganglion Strong
TS22: spinal cord ventral horn Strong
TS22: spinal cord dorsal horn Moderate
TS22: spinal cord roof plate Moderate
Specimen Table 1 E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: dorsal root ganglion Strong
TS23: spinal cord dorsal horn Strong
TS23: spinal cord roof plate Strong
TS23: spinal cord ventral horn Strong
Specimen Table 1 P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: dorsal root ganglion Strong
TS27: spinal cord dorsal horn Strong
TS27: spinal cord Strong Regionally restricted Expression is in the roof plate.
TS27: spinal cord ventral horn Moderate
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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