Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(tetO/Prnp-MAPT*K280)530Tli
Name:	transgene insertion 530, Tong Li
MGI ID:	MGI:5908855
Synonyms:	Tau4RdeltaK
Transgene:	Tg(tetO/Prnp-MAPT*K280)530Tli  Location: unknown
Alliance:	Tg(tetO/Prnp-MAPT*K280)530Tli page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO/Prnp-MAPT*K280)530Tli expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MAPT (4137) Mapt  (MGI:97180) sequence encodes a mutant deltaK280 four-repeat domain of human MAPT protein   Mutation details: The transgenic construct contains sequence encoding a mutant deltaK280 four-repeat domain of human MAPT protein (Q244-E372) under the control of the mouse Prnp gene promoter and the tetO, tetracycline-responsive regulatory element (from the moPrP-tetP vector; 42-bp tet operator sequence copies followed by the constitutively active, minimal human cytomegalovirus promoter). Frontotemporal dementia and parkinsonism is linked to human chromosome 17 Lysine 280 deletion (deltaK280 or K280del). The Lys280 deletion accelerates aggregation of MAPT (Tau). (J:240784)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:240784 Li T, et al., The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016 Jul 04;7:12082
All:	2 reference(s)