Tg(tetO/Prnp-MAPT)769Tli
Transgene Detail
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| Symbol: |
Tg(tetO/Prnp-MAPT)769Tli |
| Name: |
transgene insertion 769, Tong Li |
| MGI ID: |
MGI:5908815 |
| Synonyms: |
Tau4R, TauRD, TetO-TauRD |
| Transgene: |
Tg(tetO/Prnp-MAPT)769Tli Location: unknown Genetic Position: ChrX, Syntenic
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| Alliance: |
Tg(tetO/Prnp-MAPT)769Tli page
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| Strain of Origin: |
(C57BL/6 x SJL)F2
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| Transgene Type: |
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Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(tetO/Prnp-MAPT)769Tli expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MAPT (4137) |
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Mutation details: The transgenic construct contains sequence encoding a four-repeat domain of human MAPT protein (TauRD, Q244-E372) under the control of the mouse Prnp gene promoter and the tetO, tetracycline-responsive regulatory element (from the moPrP-tetP vector, 42-bp tet operator sequence copies followed by the constitutively active, minimal human cytomegalovirus promoter).
(J:240784)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:240784 Li T, et al., The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016 Jul 04;7:12082 |
| All: |
2 reference(s) |
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Analysis Tools
