Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Krt14tm1.1(cre/ERT2)Hjg
Name:	keratin 14; targeted mutation 1.1, Hermann-Josef Grone
MGI ID:	MGI:5908393
Synonyms:	K14CreERT2, Krt14tm1.1(cre/ERT2)Dkfz
Gene:	Krt14  Location: Chr11:100093988-100098336 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Alliance:	Krt14tm1.1(cre/ERT2)Hjg page

Germline Transmission:	Earliest citation of germline transmission: J:201085
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Krt14tm1.1(cre/ERT2)Hjg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Krt14 (MGI:96688)   Mutation details: An icre/ERT2 cassette followed by an Frt-flanked neo selection cassette was inserted into downstream of ATG-start codon in frame by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocyts. Mice were crossed to Flp-expressing mice to delete the neo cassette. (J:201085)

Activity:	Tissue activity of this recombinase allele
Driver:	Krt14 (mouse) Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities Alliance mouse Krt14 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:	36 strains or lines available

Original:	J:201085 Amen N, et al., Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum Mol Genet. 2013 Oct 15;22(20):4164-79
All:	1 reference(s)