Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Car1tm1.1(cre/ERT2)Cle
Name:	carbonic anhydrase 1; targeted mutation 1.1, Hans Clevers
MGI ID:	MGI:5908163
Synonyms:	Car1CreER
Gene:	Car1  Location: Chr3:14831274-14873425 bp, - strand  Genetic Position: Chr3, 3.18 cM
Alliance:	Car1tm1.1(cre/ERT2)Cle page

Germline Transmission:	Earliest citation of germline transmission: J:238627
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Car1tm1.1(cre/ERT2)Cle expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Car1 (MGI:88268)   Mutation details: An IRES-cre/ERT2 cassette followed by a Frt-flanked neo-selection cassette was inserted into exon 7 of the Car1 gene by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocysts. Mice were crossed to Flp-expressing mice to delete the neo cassette. (J:238627)

Activity:	Tissue activity of this recombinase allele
Driver:	Car1 (mouse) Summary of all recombinase alleles driven by Car1. Alliance mouse Car1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Car1 Mutation:	11 strains or lines available

Original:	J:238627 Tetteh PW, et al., Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11859-11864
All:	1 reference(s)