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Gene Expression Data
Assay Details
Assay
Reference: J:98713 Spencer C, et al., Distinct patterns of expression of the RB gene family in mouse and human retina. Gene Expr Patterns. 2005 Jun;5(5):687-94
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5907682
Gene symbol: Rb1
Gene name: RB transcriptional corepressor 1
Antibody: anti-Rb
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 3A pRB E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: neural retinal epithelium Present Single cells 3A E14 pRB Expression in a small number of cells scattered throughout the neuroblastic layer, coinciding with differentiation of ganglion cells.
Specimen 3A pRB P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Strong 3A P0 pRB Strong expression in ganglion cell layer into adulthood.
Specimen 3A pRB P5: postnatal day 5 (more )
Structure Level Pattern Image Note
TS28: retina Present Widespread 3A P5 pRB Expression in almost all retinal cells, including rod photoreceptors.
Specimen 3B pRB Adult mouse: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 3B Adult mouse pRB Strong expression in ganglion cell layer into adulthood.
TS28: retina inner nuclear layer Present Regionally restricted 3B Adult mouse pRB Expression in a subpopulation of inner nuclear layer cells.
TS28: photoreceptor layer Absent 3B Adult mouse pRB No expression in rod or cone photoreceptors.
Specimen 5 pRB (top row): postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 5_pRB (top row) Expression in small subset of bipolar cells.
Specimen 5 pRB (2nd row): postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 5_pRB (2nd row) No expression in amacrine cells.
Specimen 5 pRB (3rd row): postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 5_pRB (3rd row) Expression in small subset of horizontal cells.
Specimen 5 pRB (bottom row): postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 5_pRB (bottom row) Expression in the majority of Muller glia cells.
Specimen 6A pRB: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: retina Present Widespread 6A pRB Expression in almost all retinal cells, including rod photoreceptors.
Specimen 6B pRB: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Single cells 6B pRB Expression in an individual outer nuclear layer rod photoreceptor cell.
Specimen 6C pRB: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 6C pRB
TS28: retina inner nuclear layer Present Regionally restricted 6C pRB
TS28: retina outer nuclear layer Absent 6C pRB
TS28: photoreceptor layer outer segment Absent 6C pRB
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/21/2024
MGI 6.23 		The Jackson Laboratory